Precision medicine meets public health: population screening for BRCA1 and BRCA2.
نویسندگان
چکیده
Affiliations of authors: Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel (ELL); Faculty of Medicine, Hebrew University Medical School, Jerusalem, Israel (ELL, AL); Department of Family Medicine, Clalit Health Services, Jerusalem, Israel (AL); Department of Medicine and Department of Genome Sciences, University of Washington, Seattle, WA (MCK). Correspondence to: Ephrat Levy-Lahad, MD, Medical Genetics Institute, Box 3235, Shaare Zedek Medical Center, Jerusalem 91031, Israel (e-mail: lahad@ szmc.org.il).
منابع مشابه
بررسی موتاسیون های شایع ژن BRCA1 و BRCA2 در دختران مادران مبتلا به سرطان سینه و مقایسه آن با گروه کنترل
Background and purpose: Breast Cancer is one of the health problems in every population. The aim of this study was to determine the frequency of BRCA1 and BRCA2 common mutations in women whose mothers were diagnosed with breast cancer. Materials and methods: A case–control study was performed in 109 females (less than 40 years of age) who had mothers with breast cancer. For scanning of...
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Many factors including genetic, environmental, and acquired are involved in breast cancer development across various societies. Among all of these factors in families with a history of breast cancer throughout several generations, genetics, like predisposing genes to develop this disease, should be considered more. Early detection of mutation carriers in these genes, in turn, can play an import...
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THERE EXISTS AN EVER-ENLARGing literature on the prevalence of disease-associated mutations in 2 breast cancer susceptibility genes, BRCA1 and BRCA2, among women diagnosed with invasive breast cancer (IBC). Estimates of mutation rates are currently available for a number of population-based as well as high-risk groups, including women of Ashkenazi Jewish background or women with multiple family...
متن کاملDetection of BRCA1 and BRCA2 germline mutations in Japanese population using next-generation sequencing
Tumor suppressor genes BRCA1 and BRCA2 are the two main breast and ovarian cancer susceptibility genes, and their genetic testing has been used to evaluate the risk of hereditary breast and ovarian cancer (HBOC). While several studies have reported the prevalence of BRCA1 and BRCA2 mutations in Japanese populations, there is insufficient information about deleterious mutations compared with wes...
متن کاملPopulation-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2.
In the Ashkenazi Jewish (AJ) population of Israel, 11% of breast cancer and 40% of ovarian cancer are due to three inherited founder mutations in the cancer predisposition genes BRCA1 and BRCA2. For carriers of these mutations, risk-reducing salpingo-oophorectomy significantly reduces morbidity and mortality. Population screening for these mutations among AJ women may be justifiable if accurate...
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عنوان ژورنال:
- Journal of the National Cancer Institute
دوره 107 1 شماره
صفحات -
تاریخ انتشار 2015